교원섬유 기질을 이용한 3차원 세포 배양 모델에 기계적인 힘을 가하는 경우 기질을 통하여 세포에 가해지는 힘의 특성에 대한 비교 분석 연구
The finite elements analysis in the three dimensional cell culture model of the collagen matrix according to the application force
김현종, 류인철, 김성곤, 박준우,
소속 상세정보
김현종 ( Kim Hyeon-Jong ) - 서울대학교 치의학전문대학원 치주과학교실
류인철 ( Rhyu In-Chul ) - 서울대학교 치의학전문대학원 치주과학교실
김성곤 ( Kim Seong-Gon ) - 한림대학교 임상치의학연구소
박준우 ( Park Jun-Woo ) - 한림대학교 임상치의학연구소
KMID : 0355620080340020151
Abstract
Different kinds of forces can be applied to the biological tissue. The analysis of the applied force is highly important to explain the mechanism of cellular response. In this study, the applied force to the collagen gel was analyzed by the finite elements analysis. The model received two different kinds of static force (compression and tension). The force range was 50g to 400g. In results, von Mises stress was concentrated in the peripheral region in the compression model. It was concentrated in the central area in the tension model. However, the compressive force was high in the peripheral area of the compression model and the tensional force was also high in the same area of the tension model. In conclusion, the applied force could be different to the region and it should be considered in the experiment to analyze the effects of the mechanical force on the cells.
키워드
Collagen matrix;Finite element analysis;Compression;tension
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